A Multifaceted Analysis of Immune-Endocrine-Metabolic Alterations in Patients with Pulmonary Tuberculosis

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dc.contributor.author Santucci, Natalia
dc.contributor.author D'Attilio, Luciano
dc.contributor.author Kovalevski, Leandro
dc.contributor.author Bozza, Verónica
dc.contributor.author Besedovsky, Hugo
dc.contributor.author del Rey, Adriana
dc.contributor.author Bay, María Luisa
dc.contributor.author Bottasso, Oscar
dc.date.accessioned 2012-08-28T19:42:39Z
dc.date.available 2012-08-28T19:42:39Z
dc.date.issued 2011-10-13
dc.identifier.citation Santucci N, D'Attilio L, Kovalevski L, Bozza V, Besedovsky H, et al. (2011) A Multifaceted Analysis of Immune-Endocrine-Metabolic Alterations in Patients with Pulmonary Tuberculosis. PLoS ONE 6(10): e26363. doi:10.1371/journal.pone.0026363 es
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/2133/2015
dc.description.abstract Our study investigated the circulating levels of factors involved in immune-inflammatory-endocrine-metabolic responses in patients with tuberculosis with the aim of uncovering a relation between certain immune and hormonal patterns, their clinical status and in vitro immune response. The concentration of leptin, adiponectin, IL-6, IL-1β, ghrelin, C-reactive protein (CRP), cortisol and dehydroepiandrosterone (DHEA), and the in vitro immune response (lymphoproliferation and IFN-γ production) was evaluated in 53 patients with active untreated tuberculosis, 27 household contacts and 25 healthy controls, without significant age- or sex-related differences. Patients had a lower body mass index (BMI), reduced levels of leptin and DHEA, and increased concentrations of CRP, IL-6, cortisol, IL-1β and nearly significant adiponectin values than household contacts and controls. Within tuberculosis patients the BMI and leptin levels were positively correlated and decreased with increasing disease severity, whereas higher concentrations of IL-6, CRP, IL-1β, cortisol, and ghrelin were seen in cases with moderate to severe tuberculosis. Household contacts had lower DHEA and higher IL-6 levels than controls. Group classification by means of discriminant analysis and the k-nearest neighbor method showed that tuberculosis patients were clearly different from the other groups, having higher levels of CRP and lower DHEA concentration and BMI. Furthermore, plasma leptin levels were positively associated with the basal in vitro IFN-γ production and the ConA-driven proliferation of cells from tuberculosis patients. Present alterations in the communication between the neuro-endocrine and immune systems in tuberculosis may contribute to disease worsening. es
dc.description.sponsorship Grants from FONCYT (BID 1728/OC-AR PID 160) and Fundación Florencio Fiorini es
dc.format application/pdf
dc.language.iso en es
dc.publisher PLOS es
dc.rights openAccess
dc.title A Multifaceted Analysis of Immune-Endocrine-Metabolic Alterations in Patients with Pulmonary Tuberculosis es
dc.type article
dc.type artículo
dc.type publishedVersion
dc.description.peerreviewed Peer reviewed es
dc.relation.publisherversion http://dx.doi.org/10.1371/journal.pone.0026363 es
dc.rights.text © 2011 Santucci et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. es


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