A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062

DSpace/Manakin Repository

Show simple item record

dc.creator Li, Chun-shun
dc.creator Sarotti, Ariel Marcelo
dc.creator Yang, Baojun
dc.creator Turkson, James
dc.creator Cao, Shugeng
dc.date.accessioned 2020-12-22T14:51:11Z
dc.date.available 2020-12-22T14:51:11Z
dc.date.issued 2017-07-12
dc.identifier.issn 1420-3049 es
dc.identifier.uri http://hdl.handle.net/2133/19532
dc.description A new N-methoxypyridone analog (1), together with four known compounds, was isolated from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. The structure of the new compound was elucidated as 11S-hydroxy-1-methoxyfusaricide (1) by extensive spectroscopic analysis and comparison with the literature. The absolute configuration of 1 was determined by comparison with the experimental and calculated ECD spectra. The absolute configuration of compound 3 was investigated and renamed as (+)-epipyridone by comparison of the optical rotation and CD spectrum with those of 1. The other known compounds were identified as epicoccarine B (2), D8646-2-6 (4), and iso-D8646-2-6 (5). Compounds 4 and 5 showed modest inhibitory activity towards pathogenic fungi. Epicoccarine B (2) inhibited A2780 and TK-10 with an IC50 value of 22 µM. es
dc.description Para citar este articulo: Li, C.; Sarotti, A.M.; Yang, B.; Turkson, J.; Cao, S. A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. Molecules 2017, 22, 1166.
dc.description.sponsorship University of Hawaii Cancer Center es
dc.description.sponsorship University of Hawaii at Hilo es
dc.description.sponsorship Victoria S. and Bradley L. Geist Foundation: 15ADVC-74420 and 17CON-86295 es
dc.description.sponsorship National Institutes of Health (NIH)/National Cancer Institute (NCI): Grant CA128865 es
dc.format application/pdf
dc.format.extent 1-8 es
dc.language.iso eng es
dc.publisher MDPI es
dc.rights openAccess es
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ *
dc.subject Endophytic Fungi es
dc.subject Coculture Techniques es
dc.subject Pyridones es
dc.subject Tetramic Acid es
dc.subject Hawaii es
dc.title A new n-methoxypyridone from the co-cultivation of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062 es
dc.type article
dc.type artículo
dc.type publishedVersion
dc.rights.holder Universidad Nacional de Rosario es
dc.rights.holder Li, Chunshun es
dc.rights.holder Sarotti, Ariel Marcelo es
dc.rights.holder Yang, Baojun es
dc.rights.holder Turkson, James es
dc.rights.holder Cao, Shugeng es
dc.relation.publisherversion https://doi.org/10.3390/molecules22071166 es
dc.relation.publisherversion https://www.mdpi.com/1420-3049/22/7/1166 es
dc.rights.text Attribution 4.0 International (CC BY 4.0) es
dc.citation.title Molecules es
dc.citation.volume 22(7) es
dc.description.fil Fil: Li, Chun-shun. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States. es
dc.description.fil Fil: Li, Chun-shun. University of Hawaii Cancer Center. Cancer Biology Program; United States. es
dc.description.fil Fil: Sarotti, Ariel Marcelo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina. es
dc.description.fil Fil: Yang, Baojun. University of Hawaii Cancer Center. Cancer Biology Program; United States. es
dc.description.fil Fil: Turkson, James. University of Hawaii Cancer Center. Cancer Biology Program; United States. es
dc.description.fil Fil: Cao, Shugeng. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States. es
dc.description.fil Fil: Cao, Shugeng. University of Hawaii Cancer Center. Cancer Biology Program; United States. es
dc.type.collection articulo
dc.type.version publishedVersion es


Files in this item

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record

openAccess Except where otherwise noted, this item's license is described as openAccess

My Account


Search DSpace


Browse