Antimicrobial activity of quinoline-based hydroxyimidazolium hybrids

DSpace/Manakin Repository

Show simple item record

dc.creator Insuasty, Daniel
dc.creator Vidal, Oscar
dc.creator Bernal, Anthony
dc.creator Marquez, Edgar
dc.creator Guzman, Juan
dc.creator Insuasty, Braulio
dc.creator Svetaz, Laura
dc.creator Zacchino, Susana
dc.creator Puerto, Gloria
dc.date.accessioned 2020-12-16T21:37:42Z
dc.date.available 2020-12-16T21:37:42Z
dc.date.issued 2019-11-28
dc.identifier.issn 2079-6382 es
dc.identifier.uri http://hdl.handle.net/2133/19489
dc.description Eight quinoline-based hydroxyimidazolium hybrids 7a–h were prepared and evaluated in vitro against a panel of clinically important fungal and bacterial pathogens, including mycobacteria. Hybrid compounds 7c–d showed remarkable antifungal activity against Cryptococcus neoformans with a minimum inhibitory concentration (MIC) value of 15.6 µg/mL. Against other opportunistic fungi such as Candida spp. and Aspergillus spp., these hybrids showed MIC values of 62.5 µg/mL. Regarding their antibacterial activity, all the synthetic hybrids demonstrated little inhibition of Gram-negative bacteria (MIC ≥50 µg/mL), however, hybrid 7b displayed >50% inhibition against Klebsiella pneumoniae at 20 µg/mL and full inhibition at 50 µg/mL. Moreover, this hybrid was shown to be a potent anti-staphylococcal molecule, with a MIC value of 2 µg/mL (5 µM). In addition, hybrid 7h also demonstrated inhibition of Staphylococcus aureus at 20 µg/mL (47 µM). Hybrids 7a and 7b were the most potent against Mycobacterium tuberculosis H37Rv with MIC values of 20 and 10 µg/mL (46 and 24 µM), respectively. The 7b hybrid demonstrated high selectivity in killing S. aureus and M. tuberculosis H37Rv in comparison with mammalian cells (SI >20), and thus it can be considered a hit molecule for mechanism of action studies and the exploration of related chemical space. es
dc.description Para citar este articulo: Insuasty, D.; Vidal, O.; Bernal, A.; Marquez, E.; Guzman, J.; Insuasty, B.; Quiroga, J.; Svetaz, L.; Zacchino, S.; Puerto, G.; Abonia, R. Antimicrobial Activity of Quinoline-Based Hydroxyimidazolium Hybrids. Antibiotics 2019, 8, 239.
dc.description.sponsorship Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT2016-1833 es
dc.description.sponsorship Universidad Nacional de Rosario (UNR) es
dc.description.sponsorship Departamento Administrativo de Ciencia, Tecnología e Innovación (Colciencias) es
dc.description.sponsorship Universidad del Valle es
dc.description.sponsorship Universidad del Norte es
dc.format application/pdf
dc.format.extent 1-11 es
dc.language.iso eng es
dc.publisher MDPI es
dc.rights openAccess es
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ *
dc.subject Quinoline-based Hydroxyimidazolium Hybrids es
dc.subject Antimicrobial Activity es
dc.subject Antifungal Activity es
dc.subject Tuberculosis es
dc.subject Cytotoxicity es
dc.title Antimicrobial activity of quinoline-based hydroxyimidazolium hybrids es
dc.type article
dc.type artículo
dc.type publishedVersion
dc.rights.holder Universidad Nacional de Rosario es
dc.rights.holder Insuasty, Daniel es
dc.rights.holder Vidal, Oscar es
dc.rights.holder Bernal, Anthony es
dc.rights.holder Marquez, Edgar es
dc.rights.holder Guzman, Juan es
dc.rights.holder Insuasty, Braulio es
dc.rights.holder Svetaz, Laura es
dc.rights.holder Zacchino, Susana es
dc.relation.publisherversion https://doi.org/10.3390/antibiotics8040239 es
dc.relation.publisherversion https://www.mdpi.com/2079-6382/8/4/239#cite es
dc.rights.text Attribution 4.0 International (CC BY 4.0) es
dc.citation.title Antibiotics es
dc.citation.volume 8(4) es
dc.description.fil Fil: Insuasty, Daniel. Universidad del Norte. Departamento de Química y Biología; Colombia. es
dc.description.fil Fil: Vidal, Oscar. Universidad del Norte. Departamento de Química y Biología; Colombia. es
dc.description.fil Fil: Bernal, Anthony. Universidad del Norte. Departamento de Química y Biología; Colombia. es
dc.description.fil Fil: Marquez, Edgar. Universidad del Norte. Departamento de Química y Biología; Colombia. es
dc.description.fil Fil: Guzman, Juan. Justus Liebig University Giessen. Institute for Insect Biotechnology; Germany. es
dc.description.fil Fil: Insuasty, Braulio. Universidad del Valle. Facultad de Ciencias Naturales y Exactas. Departamento de Química. Grupo de Investigación de Compuestos Heterocíclicos; Colombia. es
dc.description.fil Fil: Svetaz, Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Farmacognosia; Argentina. es
dc.description.fil Fil: Zacchino, Susana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área Farmacognosia; Argentina. es
dc.description.fil Fil: Puerto, Gloria. Instituto Nacional de Salud. Laboratorio de Micobacterias; Colombia. es
dc.type.collection articulo
dc.type.version publishedVersion es


Files in this item

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record

openAccess Except where otherwise noted, this item's license is described as openAccess

My Account


Search DSpace


Browse