Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells

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dc.contributor.author Rozados, Viviana R.
dc.contributor.author Hinrichsen, Lucila Isabel
dc.contributor.author McDonnel, José
dc.contributor.author Scharovsky, O. Graciela
dc.date.accessioned 2012-07-12T14:58:33Z
dc.date.available 2012-07-12T14:58:33Z
dc.date.issued 1905-06-27
dc.identifier.citation Rozados VR, Hinrichsen LI, McDonnell J & Scharovsky O. G (2005) Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells. J Exp Clin Cancer Res 24:55–61. es
dc.identifier.issn 0392-9078
dc.identifier.uri http://hdl.handle.net/2133/1936
dc.description.abstract Our previous demonstration of an antimetastatic effect of lovastatin, both in rat sarcoma and lymphoma tumor-models, as well as the fact that lovastatin and radiation are able to stop the cell cycle in different phases, suggested the feasibility of a combined treatment. We studied the effect of the in vitro combined treatment of a B-cell rat lymphoma (L-TACB) with lovastatin and irradiation. The results herein obtained provide new information about the role of statins as radiosensitizers. The antitumor effect of the combined treatment was higher than that elicited by either treatment alone. This effect could be a consequence, at least in part, of an enhanced apoptosis. es
dc.format application/pdf
dc.language.iso en es
dc.publisher BioMed Central; "Regina Elena" National Cancer Institute, Italy es
dc.rights openAccess
dc.subject.mesh Lovastatin/pharmacology
dc.subject.mesh Animals
dc.subject.mesh Apoptosis/drug effects
dc.subject.mesh Apoptosis/radiation effects
dc.subject.mesh B-Lymphocytes/drug effects
dc.subject.mesh B-Lymphocytes/pathology
dc.subject.mesh B-Lymphocytes/radiation effects
dc.subject.mesh Female
dc.subject.mesh Male
dc.subject.mesh Rats
dc.subject.mesh Tumor Cells, Cultured
dc.title Lovastatin enhances in vitro radiation-induced apoptosis of rat B-cell lymphoma cells es
dc.type article
dc.type artículo
dc.type publishedVersion
dc.description.peerreviewed Peer reviewed es
dc.relation.publisherversion http://195.135.200.83/allegatiifo/rivista/anno2005/1/55.pdf es


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